Interactions between Single Fibrin Fibers are Measured for the First Time

Cells and tissue change their structural properties to cope with large strains e.g. caused by blood flow and external stress. Understanding microstructural remodeling of the extracellular matrix requires knowledge of biological events down to the smallest scale. One of the … Continue Reading

Paper Using LUMICKS Technology Published in Nature

Great news: Another paper using LUMICKS technology was published, this time in Nature! Congratulations to the authors. Several are now part of LUMICKS. In the study “Sliding sleeves of XRCC4-XLF bridge DNA and connect fragments of broken DNA” Brouwer et al. … Continue Reading

Study using CTFM Published in Nature Communications

A new paper using the correlative optical tweezers-fluorescence microscopy (CTFM) technology has recently been published in Nature Communications. King, Peterman & Wuite show in “Unravelling the structural plasticity of stretched DNA under torsional constraint” that in torsionally constraint DNA concomitant … Continue Reading

AFS™ 2.0 Paper Published in Methods

The second paper on the Acoustic Force Spectroscopy (AFS™) technology has been published in Methods. In “Tuning the Music: Acoustic Force Spectroscopy (AFS) 2.0” Kamsma and his colleagues at VU University Amsterdam describe the latest developments on the technology. In … Continue Reading

AFS™ Featured in Nature Methods

The novel method of using acoustics for single molecule manipulation and spectroscopy was published in the January 2015 edition of Nature methods. Force spectroscopy has become an indispensable tool to unravel the structural and mechanochemical properties of biomolecules. Here we extend … Continue Reading

CTFM Results on RAD51 Appear in PNAS

In a recent publication, Correlative Tweezers-Fluorescence Microscopy was used to reveal a fundamental step in one of the most crucial biological process that occur in a cell: DNA repair. The article appeared in the renowned journal PNAS, and was portrayed … Continue Reading

Super Resolution CTFM in Nature Methods

Super Resolution Correlative Tweezers Fluorescence Microscopy (SR-CTFM) was featured in Nature Methods. The VU team presented the CTFM single-molecule approach capable of visualizing individual DNA-binding proteins on densely covered DNA and in the presence of high protein concentrations. The method … Continue Reading